Michael Mina

img_4491Graduate student, MD/PhD
michael.j.mina@gmail.com

I study the complexities and dynamics that drive or prevent infectious diseases through a combination of clinical and laboratory studies and mathematical modeling. My major focus centers around long-term immunologic effects of measles on immune-memory homeostasis and immune repertoire diversity. In particular, I am interested in how a short term infection with measles perturbs the long-term immune memory pool, thus altering long-term susceptibility to other infectious diseases.

I am also particularly interested in unintended effects of vaccinations on individuals and populations towards non-vaccine target infectious diseases. For instance, by reducing measles across the global population, measles vaccinations not only reduce measles infections, but I find also have played a large part in reducing susceptibility and deaths due perhaps to all other infectious diseases. A slightly different but related area of research, I have found that live attenuated influenza vaccines enhance nasopharyngeal carriage of pathogenic bacteria (S. pneumoniae and S. aureus). At the individual level, the vaccine alters growth dynamics of the bacterial pathogens, and, because these alterations may well enhance bacterial transmission in a density dependent fashion, the live influenza vaccine may effect unrelated bacterial pathogens at the population level as well. I think of this as an extension of the vaccine herd effect, allowing herd effects of vaccines to impact non-vaccine targeted pathogen dynamics amongst unvaccinated individuals.

Sinead E. Morris

Sinead Morris

Graduate student
sineadmorris3@gmail.com

I am broadly interested in integrating immunological and epidemiological data to model the cross-scale dynamics of infectious diseases. Current projects include quantifying the impact of within-host viral persistence on population-level transmission. During my graduate research I have also worked on the spatiotemporal dynamics of a range of acute infections including measles, dolphin morbillivirus and human influenza; and previously, at the University of Glasgow, I modeled the development of new blood vessels in response to tumour growth and the spread of infectious diseases on agricultural networks.

Personal website: https://sineadmorris.wordpress.com/

 

Alex Becker

Alex Becker

Graduate student
adbecker@princeton.edu

I am interested in models of infectious disease spread at the population level. My current research is focused on the cross-scale dynamics of measles with emphasis on the school- and community-level. Additionally, I’m interested in expanding the methods used to fit time series data. Previous research has focused on modeling within host dynamics of tuberculosis and statistical inference of measles incidence data.